AGASTACHE RUGOSA EXTRACT HAVING ANTI-INFLAMMATORY ACTIVITY AND ANTI-ATHEROGENIC ACTIVITY

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EP 1 363 648 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	25.04.2007 Bulletin 2007/17

(45)	Mention of the grant of the patent:
	15.11.2006 Bulletin 2006/46

(21)	Application number: 01274005.6

(22)	Date of filing: 20.12.2001

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International Patent Classification (IPC):

A61K 31/704^(2006.01)
A61P 29/00^(2006.01)

A61P 3/10^(2006.01)
A61K 36/532^(2006.01)

(86)	International application number:
	PCT/KR2001/002224

(87)	International publication number:
	WO 2002/074320 (26.09.2002 Gazette 2002/39)

(54)	AGASTACHE RUGOSA EXTRACT HAVING ANTI-INFLAMMATORY ACTIVITY AND ANTI-ATHEROGENIC ACTIVITY AGASTACHE RUGOSA EXTRAKT MIT ENTZÜNDUNGSHEMMENDER WIRKUNG UND ANTIATHEROGENER WIRKUNG EXTRAIT D'AGASTACHE RUGOSA DOTE D'UNE ACTIVITE ANTI-INFLAMMATOIRE ET ACTIVITE ANTI-ATHEROGENE

(84)	Designated Contracting States:
	DE FR

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Priority:

27.02.2001 KR 2001009977

(43)	Date of publication of application:
	26.11.2003 Bulletin 2003/48

(73)	Proprietor: Korea Research Institute of Bioscience and Biotechnology
	Daejeon 305-333 (KR)

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Inventors:

LEE, Hyeong Kyu
305-755 Daejeon (KR)
OH, Sei Ryang, Apt. 1130
302-724 Daejeon (KR)
AHN, Kyung Seop
305-755 Daejeon (KR)
CHOI, Soon Ja
305-503 Daejeon (KR)
KIM, Jung Hee
314-150 Gongju-si, Choongcheong-namdo (KR)
OH, Goo Taeg
305-755 Daejeon (KR)
HONG, Jung Joo
137-771 Seoul (KR)
PARK, Seong Kyu
314-833 Gongju-si, Choongcheong-namdo (KR)
NAMKUNG, Woo, 933-304 GajokSaenghwaldong
151-057 Seoul (KR)

(74)	Representative: Andrews, Timothy Stephen et al
	Marks & Clerk 90 Long Acre London WC2E 9RA London WC2E 9RA (GB)

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References cited: :

US-A- 5 776 462

OH S R ET AL: "In vitro anticomplementary activity of phenylpropanoids from Agastache rugosa" KOREAN JOURNAL OF PHARMACOGNOSY 1996 SOUTH KOREA, vol. 27, no. 1, 1996, pages 20-25, XP009040574 ISSN: 0253-3073
HONG JUNG-JOO ET AL: "Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa" FEBS LETTERS, vol. 495, no. 3, 27 April 2001 (2001-04-27), pages 142-147, XP002309258 ISSN: 0014-5793
DATABASE WPI Section Ch, Week 200260 Derwent Publications Ltd., London, GB; Class B04, AN 2002-563525 XP002309260 & KR 2002 012 435 A (HAN W S) 16 February 2002 (2002-02-16)
CHONG P H ET AL: "CURRENT, NEW AND FUTURE TREATMENTS IN DYSLIPIDAEMIA AND ATHEROSCLEROSIS" DRUGS, ADIS INTERNATIONAL LTD, AT, vol. 60, no. 1, July 2000 (2000-07), pages 55-93, XP008010516 ISSN: 0012-6667
KIRSCHFINK M: "CONTROLLING THE COMPLEMENT SYSTEM IN INFLAMMATION" IMMUNOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, XX, vol. 38, no. 1/2, December 1997 (1997-12), pages 51-62, XP000856857 ISSN: 0162-3109
ROTHLEIN R ET AL: "TREATMENT OF INFLAMMATION WITH ANTI-ICAM-1" RESEARCH IN IMMUNOLOGY, PARIS, FR, vol. 144, no. 9, November 1993 (1993-11), pages 735-739,754, XP000575989
MOHRI MASAHIRO ET AL: "Coronary microvascular disease in humans" JAPANESE HEART JOURNAL, vol. 40, no. 2, March 1999 (1999-03), pages 97-108, XP002309259 ISSN: 0021-4868
HAYASHI T ET AL: "INHIBITION OF COW'S MILK XANTHINE OXIDASE BY FLAVONOIDS" JOURNAL OF NATURAL PRODUCTS, XX, XX, vol. 51, no. 2, March 1988 (1988-03), pages 345-348, XP002911729 ISSN: 0163-3864
YAO XUE XUE BAO vol. 26, no. 12, 1991, pages 906 - 910, XP002972547
ARCH. PHARM. RES. vol. 22, no. 5, October 1999, pages 520 - 523, XP001026715
JORNAL OF NATURAL PRODUCTS vol. 58, no. 11, November 1995, pages 1718 - 1721, XP002972548

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).