(19)

(11)

EP 1 363 916 A2

(12)

(88) Date of publication A3: 05.06.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 02763188.6 (22) Date of filing: 26.02.2002

(51) International Patent Classification (IPC)7: C07D 487/22 (86) International application number: PCT/US0205/584 (87) International publication number: WO 0210/4072 (27.12.2002 Gazette 2002/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.02.2001 US 271520 P 19.07.2001 US 306504 P (71) Applicant: The Trustees of The University of Pennsylvania Philadelphia,Pennsylvania 19104-6283 (US)	(72) Inventor: THERIEN, Michael, J. Philadelphia, PA 19103 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)