(19)

(11)

EP 1 364 004 A2

(12)

(88) Date of publication A3: 02.10.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 01997073.0 (22) Date of filing: 12.12.2001

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/63, C12N 5/00 (86) International application number: PCT/US0148/726 (87) International publication number: WO 0206/1037 (08.08.2002 Gazette 2002/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.12.2000 US 255021 P (71) Applicants: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US) Advisys The Woodlands, TX 77380 (US)	(72) Inventors: SCHWARTZ, Robert, J. Houston, TX 77005 (US) CARPENTER, Robert, H. Bastrop, TX 78602 (US) DRAGHIA-AKLI, Ruxandra Houston, TX 77035 (US) KERN, Douglas, R. The Woodlands, TX 77381 (US) SMITH, Roy, G. Houston, TX 77005 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)