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(11)

EP 1 364 013 A1

(12)

(43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 01910628.5 (22) Date of filing: 14.02.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, G01N 33/68 (86) International application number: PCT/US0104/641 (87) International publication number: WO 0206/4789 (22.08.2002 Gazette 2002/34)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)	(72) Inventors: LIND, Peter S-751 29 Uppsala (SE) PARODI, Luis, A. S-115 43 Stockholm (SE) VOGELI, Gabriel Seattle, WA 98121 (US) WOOD, Linda, S. Portage, MI 49024 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)