(19)

(11)

EP 1 364 017 A2

(12)

(88) Date of publication A3: 10.07.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 01980246.1 (22) Date of filing: 16.08.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12N 15/11, C07K 16/28, G01N 33/50, A61K 39/395, A61K 38/17, A61K 31/7105 (86) International application number: PCT/EP0109/466 (87) International publication number: WO 0201/3845 (21.02.2002 Gazette 2002/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.08.2000 US 641653 (71) Applicants: Novartis AG 4002 Basel (CH) BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR  Novartis Pharma GmbH 1230 Wien (AT) AT	(72) Inventors: JARAI, Gabor,Novartis Horsham Research Centre Horsham,West Sussex RH12 5AB (GB) YOUSEFI, Shida CH-3013 Bern (CH) (74) Representative: Gros, Florent  Novartis AG 4002 Basel 4002 Basel (CH)