(19)

(11)

EP 1 364 033 A2

(12)

(88) Date of publication A3: 12.09.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 01988167.1 (22) Date of filing: 21.11.2001

(51) International Patent Classification (IPC)7: C12N 15/82, C12N 15/29, C07K 14/415, C12N 5/10, A01H 5/00 (86) International application number: PCT/US0143/750 (87) International publication number: WO 0204/4390 (06.06.2002 Gazette 2002/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.11.2000 US 253415 P (71) Applicant: E.I. DUPONT DE NEMOURS AND COMPANY Wilmington,Delaware 19898 (US)	(72) Inventors: CAHOON, Edgar, B. Wilmington, DE 19806 (US) CAHOON, Rebecca, E. Wilmington, DE 19806 (US) KLEIN, Theodore, M. Wilmington, DE 19810 (US) RAFALSKI, Antoni, J. Wilmington, DE 19810 (US) SAKAI, Hajime Newark, DE 19711 (US) (74) Representative: Bentham, Andrew  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)