(19)

(11)

EP 1 364 052 A2

(12)

(88) Date of publication A3: 25.09.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 01979708.3 (22) Date of filing: 10.10.2001

(51) International Patent Classification (IPC)7: C12Q 1/68, B01J 19/00, B01L 3/00, G01N 21/03, C12N 15/10 (86) International application number: PCT/US0131/806 (87) International publication number: WO 0203/1203 (18.04.2002 Gazette 2002/16)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.10.2000 US 685432 15.12.2000 US 738871 21.02.2001 US 790321 27.06.2001 US 894956 31.07.2001 US 309101 P (71) Applicant: DIVERSA CORPORATION San Diego, CA 92121 (US)	(72) Inventors: SHORT, Jay, M. Rancho Santa Fe, CA 92067 (US) KELLER, Martin San Diego, CA 92129 (US) LAFFERTY, William, Michael Encinitas, CA 92024 (US) (74) Representative: Cornish, Kristina Victoria Joy  Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)