(19)

(11)

EP 1 364 058 A2

(12)

(88) Date of publication A3: 12.09.2003 (43) Date of publication: 26.11.2003 Bulletin 2003/48 (21) Application number: 01999673.5 (22) Date of filing: 06.12.2001

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/JP0110/689 (87) International publication number: WO 0204/6468 (13.06.2002 Gazette 2002/24)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 08.12.2000 US 251855 P (71) Applicant: Riken Wako-shi,Saitama 351-0198 (JP)	(72) Inventors: HAYASHIZAKI, Yoshihide Tsukuba-shi, Ibaraki 305-0061 (JP) ONO, Tetsuyoshi Hitachinaka-shi,Ibaraki 312-0033 (JP) (74) Representative: Arends, William Gerrit et al Lloyd WiseCommonwealth House1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)