(19)

(11)

EP 1 365 785 A2

(12)

(88) Date of publication A3: 10.07.2003 (43) Date of publication: 03.12.2003 Bulletin 2003/49 (21) Application number: 01937817.3 (22) Date of filing: 22.05.2001

(51) International Patent Classification (IPC)7: A61K 38/00 (86) International application number: PCT/US0140/783 (87) International publication number: WO 0108/9550 (29.11.2001 Gazette 2001/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.05.2000 US 577468 (71) Applicant: REGENERON PHARMACEUTICALS, INC. Tarrytown, NY 10591-6707 (US)	(72) Inventors: WONG, Vivien, W. Scarsdale, NY 10583 (US) KOEHLER-STEC, Ellen, M. New York 10512 (US) STAHL, Neil Carmel, NY 10512 (US) (74) Representative: Duckworth, Timothy John  J.A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)