(19)

(11)

EP 1 365 803 A2

(12)

(88) Date of publication A3: 10.07.2003 (43) Date of publication: 03.12.2003 Bulletin 2003/49 (21) Application number: 01966515.7 (22) Date of filing: 30.08.2001

(51) International Patent Classification (IPC)7: A61K 39/395 (86) International application number: PCT/US0127/296 (87) International publication number: WO 0201/7962 (07.03.2002 Gazette 2002/10)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.08.2000 US 229869 P (71) Applicant: Oregon Health and Science University Portland, Oregon 97201 (US)	(72) Inventors: NEUWELT, Edward, A. Portland, OR 97201 (US) MULDOON, Leslie Tigard, OR 97223 (US) (74) Representative: Ward, David Ian  Marks & Clerk,Alpha Tower,Suffolk Street,Queensway Birmingham B1 1TT Birmingham B1 1TT (GB)