(19)

(11)

EP 1 365 855 A2

(12)

(88) Date of publication A3: 18.09.2003 (43) Date of publication: 03.12.2003 Bulletin 2003/49 (21) Application number: 01273634.4 (22) Date of filing: 05.11.2001

(51) International Patent Classification (IPC)7: B01F 11/02 (86) International application number: PCT/US0144/451 (87) International publication number: WO 0207/9751 (10.10.2002 Gazette 2002/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.11.2000 US 247572 P (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)

(72) Inventors: AUDAIN, Vaughn A.;c/o GlaxoSmithKline Research Triangle Park,NC 27709 (US) BUCKNER, Charles A.;c/o GlaxoSmithKline Research Triangle Park,NC 27709 (US) GEYSEN, Hendrick M.;c/o University of Virginia Charlottesville, VA 22904 (US) ORMAND, James R.;c/o GlaxoSmithKline Research Triangle Park,NC 27709 (US) (74) Representative: Thornley, Rachel Mary  GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)