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EP 1 370 250 A2

(12)

(88) Date of publication A3: 01.05.2003 (43) Date of publication: 17.12.2003 Bulletin 2003/51 (21) Application number: 02715187.7 (22) Date of filing: 21.03.2002

(51) International Patent Classification (IPC)7: A61K 31/00, A61K 31/4245, A61K 31/44, A61K 31/4439, A61K 31/444, A61K 31/506, A61K 31/53, C07D 403/14, A61P 9/00, A61P 9/10, A61P 35/00, A61P 27/02, A61P 19/02 (86) International application number: PCT/US0208/862 (87) International publication number: WO 0207/6438 (03.10.2002 Gazette 2002/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 23.03.2001 US 278156 P (71) Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA Tokyo, 115-8543 (JP)

(72) Inventors: ARRHENIUS, Thomas,Chugai Biopharmaceuticals, Inc. San Diego, CA 92121 (US) HUANG, Yujin,c/o Chugai Biopharmaceuticals, Inc. San Diego, CA 92121 (US) ZHANG, Lin,c/o Chugai Biopharmaceuticals, Inc. San Diego, CA 92121 (US) SERAFIMOV, Rossy,Chugai Biopharmaceuticals, Inc. San Diego, CA 92121 (US) NADZAN, Alex,c/o Chugai Biopharmaceuticals, Inc. San Diego, CA 92121 (US) SPINELLA, Dominic,Chugai Biopharmaceuticals, Inc. San Diego, CA 92121 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)