(19)

(11)

EP 1 370 267 A2

(12)

(88) Date of publication A3: 03.04.2003 (43) Date of publication: 17.12.2003 Bulletin 2003/51 (21) Application number: 02719062.8 (22) Date of filing: 22.02.2002

(51) International Patent Classification (IPC)7: A61K 31/52, A61P 27/06 (86) International application number: PCT/US0205/456 (87) International publication number: WO 0207/6460 (03.10.2002 Gazette 2002/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 21.03.2001 US 277548 P (71) Applicant: Alcon, Inc. 6331 Hünenberg (CH)	(72) Inventors: PANG, Iok-Hou Grand Prairie, TX 75052 (US) HELLBERG, Mark, R. Highland Village, TX 75077 (US) CLARK, Abbot, F. Arlington, TX 76017 (US) HELLBERG, Peggy, E. Highland Village, TX 75077 (US) SHADE, Debra, L. Benbrook, TX 76126 (US) (74) Representative: Wain, Christopher Paul et al A.A. Thornton & Co.235 High Holborn London WC1V 7LE London WC1V 7LE (GB)