(19)

(11)

EP 1 370 642 A2

(12)

(88) Date of publication A3: 16.10.2003 (43) Date of publication: 17.12.2003 Bulletin 2003/51 (21) Application number: 02712824.8 (22) Date of filing: 18.01.2002

(51) International Patent Classification (IPC)7: C12N 5/08, A61K 35/12, G01N 33/50, A61P 37/00 (86) International application number: PCT/EP0200/475 (87) International publication number: WO 0205/7430 (25.07.2002 Gazette 2002/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.01.2001 EP 01101333 27.04.2001 US 287105 P 21.09.2001 US 324008 P (71) Applicant: Cardion AG 40699 Erkrath (DE)	(72) Inventors: SORIA ESCOMS, Bernat E-03540 Alicante (ES) BERNA AMOROS, Genoveva E-03560 Campello, Alicante (ES) REIG MACIA, Juan Antonio E-03004 Alicante (ES) MARTIN BERMUDO, Franz E-03560 Campello, Alicante (ES) ENSENAT WASSER, Roberto E-03016 Alicante (ES)