(19)

(11)

EP 1 370 659 A2

(12)

(88) Date of publication A3: 25.09.2003 (43) Date of publication: 17.12.2003 Bulletin 2003/51 (21) Application number: 02761846.1 (22) Date of filing: 16.01.2002

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 5/10, C12N 1/21, C07K 14/47, C07K 16/18, C12Q 1/68, G01N 33/53, G01N 33/50 (86) International application number: PCT/US0201/311 (87) International publication number: WO 0206/8647 (06.09.2002 Gazette 2002/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.01.2001 US 261376 18.01.2001 US 262454 18.01.2001 US 262587 31.01.2001 US 265530 14.02.2001 US 268595 28.02.2001 US 272409 16.03.2001 US 276777 17.05.2001 US 291672 27.09.2001 US 325306 18.10.2001 US 330336 09.11.2001 US 345202 (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)

(72) Inventors: PADIGARU, Muralidhara Branford, CT 06405 (US) ALSOBROOK, John, P., II Madison, CT 06443 (US) COLMAN, Steven, D. Guilford, CT 06437 (US) SPYTEK, Kimberly, A. New Haven, CT 06511 (US) BOLDOG, Ferenc North Haven, CT 06473 (US) VERNET, Corine, A., M. North Branford, CT 06471 (US) LI,Li Branford, CT 06405 (US) SHENOY, Suresh Branford, CT 06405 (US) CASMAN, Stacie North Haven, CT 06473 (US) GUO, Xiaojia Branford, CT 06405 (US) EDINGER, Shlomit New Haven, CT 06515 (US) MACDOUGALL, John Hamden, CT 06517 (US) MALYANKAR, Uriel, M. Branford, CT 06405 (US) PATTURAJAN, Meera Branford, CT 06405 (US) SHIMKETS, Richard, A. Guilford, CT 06437 (US) PENA, Carol New Haven, CT 06511 (US) TCHERNEV, Velizar Branford, CT 06405 (US) ZERHUSEN, Bryan, D. Branford, CT 06405 (US) MILLET, Isabelle Milford, CT 06460 (US) MILLER, Charles, E. Guilford, CT 06437 (US) LEPLEY, Denise, M. Bransford, CT 06405 (US) SMITHSON, Glennda Guilford, CT 06405 (US) BAUMGARTNER, Jason New Haven, CT 06513 (US) HERRMANN, John Guilford, CT 06437 (US) PEYMAN, John, A. New Haven, CT 06515 (US) GORMAN, Linda Branford, CT 06405 (US) MEZES, Peter Old Lyme, CT 06371 (US) MEZES, Peter Old Lyme, CT 06371 (US) TAUPIER, Raymond, J., Jr. East Haven, CT 06512 (US) GERLACH, Valerie Bransford, CT 06405 (US) GROSSE, William, M. Bransford, CT 06405 (US) LIU, Xiaohong Branford, CT 06405 (US) ELLERMAN, Karen Branford, CT 06405 (US) ROTHENBERG, Mark Clinton, CT 06413 (US) STONE, David, J. Guilford, CT 06437 (US) BURGESS, Catherine, E. Wethersfield, CT 06109 (US) KEKUDA, Ramesh Stamford, CT 06902 (US) (74) Representative: Taylor, Kathryn May et al Mathys & Squire,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)