(19)
(11) EP 1 372 660 A2

(12)

(88) Date of publication A3:
16.10.2003

(43) Date of publication:
02.01.2004 Bulletin 2004/01

(21) Application number: 01952530.2

(22) Date of filing: 05.07.2001
(51) International Patent Classification (IPC)7A61K 31/52, A61K 31/675, A61K 31/64, A61P 5/00
(86) International application number:
PCT/US2001/021557
(87) International publication number:
WO 2002/003978 (17.01.2002 Gazette 2002/03)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 06.07.2000 US 216531 P

(71) Applicants:
  • Metabasis Therapeutics, Inc.
    San Diego, CA 92121 (US)
  • Sankyo Company, Limited
    Tokyo 140-8710 (JP)

(72) Inventors:
  • VAN POELJE, Paul, D.
    La Jolla, CA 92037 (US)
  • ERION, Mark, D.
    Del Mar, CA 92014 (US)
  • FUJIWARA, Toshihiko,Sankyo Company, Limited
    Shinagawa-ku,Tokyo 140-8710 (JP)

(74) Representative: Sexton, Jane Helen 
J.A. KEMP & CO.14 South SquareGray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) A COMBINATION OF FBPASE INHIBITORS AND ANTIDIABETIC AGENTS USEFUL FOR THE TREATMENT OF DIABETES