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(11)

EP 1 372 713 A1

(12)

(43) Date of publication: 02.01.2004 Bulletin 2004/01 (21) Application number: 02757899.6 (22) Date of filing: 01.04.2002

(51) International Patent Classification (IPC)7: A61K 39/38 (86) International application number: PCT/US2002/010025 (87) International publication number: WO 2002/078737 (10.10.2002 Gazette 2002/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.04.2001 US 281106 P (71) Applicant: GENENCOR INTERNATIONAL, INC. Palo Alto, California 94304 (US)	(72) Inventors: GREEN, Thomas, S. Montara, CA 94037 (US) DALE, Douglas, A. Pacifica, CA 94044 (US) (74) Representative: HOFFMANN - EITLE  Patent- und RechtsanwälteArabellastrasse 4 81925 München 81925 München (DE)