(19)

(11)

EP 1 372 742 A2

(12)

(88) Date of publication A3: 23.10.2003 (43) Date of publication: 02.01.2004 Bulletin 2004/01 (21) Application number: 01273840.7 (22) Date of filing: 16.11.2001

(51) International Patent Classification (IPC)7: A61K 51/12, A61N 5/10, A61K 49/04, A61K 41/00, A61K 47/48 (86) International application number: PCT/US2001/043517 (87) International publication number: WO 2002/068000 (06.09.2002 Gazette 2002/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.11.2000 US 249128 P 18.05.2001 US 861196 18.05.2001 US 861326 (71) Applicant: Microspherix LLC Boca Raton, FL 33428 (US)	(72) Inventor: KAPLAN, Edward, J. Boca Raton, FL 33428 (US) (74) Representative: Bassett, Richard Simon  Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)