(19)

(11)

EP 1 373 501 A2

(12)

(88) Date of publication A3: 09.10.2003 (43) Date of publication: 02.01.2004 Bulletin 2004/01 (21) Application number: 01986322.4 (22) Date of filing: 05.10.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/62, C12N 15/86, C12N 15/47, C07K 14/705, A61K 48/00, G01N 33/50 (86) International application number: PCT/EP2001/011514 (87) International publication number: WO 2002/029072 (11.04.2002 Gazette 2002/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.10.2000 US 684552 06.10.2000 US 327562 P (71) Applicants: Novartis AG 4056 Basel (CH) BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR  Novartis Pharma AG 1230 Vienna (AT) AT	(72) Inventors: KIM, Jin, Gwan Germantown, MD 20876 (US) SMITH, Theodore Ijamsville, MD 21754 (US) STEVENSON, Susan, C. Frederick, MD 21701 (US) KALEKO, Michael Rockville, MD 20854 (US) (74) Representative: Gros, Florent  Novartis AG 4002 Basel 4002 Basel (CH)