INHIBITION OF ERK TO REDUCE OR PREVENT TOLERANCE TO AND DEPENDENCE ON OPIOID ANALGESICS - Patent 1377279

(19)

(11)

EP 1 377 279 A2

(12)

(88)	Date of publication A3:
	09.10.2003

(43)	Date of publication:
	07.01.2004 Bulletin 2004/02

(21)	Application number: 02717370.7

(22)	Date of filing: 25.01.2002

(51)	International Patent Classification (IPC)⁷: A61K 31/00, A61K 31/7088, A61K 38/45

(86)	International application number:
	PCT/US2002/002128

(87)	International publication number:
	WO 2002/058687 (01.08.2002 Gazette 2002/31)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
	Designated Extension States:
	AL LT LV MK RO SI

(30)

Priority:

25.01.2001 US 264336 P

(71)	Applicant: Board of Regents,The University of Texas System
	AustinTexas 78701 (US)

(72)	Inventor:
	GUTSTEIN, Howard, B. Houston, TX 77030 (US)

(74)	Representative: Dehmel, Albrecht, Dr.
	Herzogspitalstrasse 11 80331 München 80331 München (DE)

(54)	INHIBITION OF ERK TO REDUCE OR PREVENT TOLERANCE TO AND DEPENDENCE ON OPIOID ANALGESICS