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(11)

EP 1 377 312 A1

(12)

(43) Date of publication: 07.01.2004 Bulletin 2004/02 (21) Application number: 02725277.4 (22) Date of filing: 22.03.2002

(51) International Patent Classification (IPC)7: A61K 38/48, A01N 43/32, A01N 43/50, A01N 37/18, A01N 31/08 (86) International application number: PCT/US2002/008656 (87) International publication number: WO 2002/076496 (03.10.2002 Gazette 2002/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.03.2001 US 277625 P (71) Applicant: Van Andel Institute Grand Rapids, MI 49503 (US)	(72) Inventors: DUESBERY, Nicholas, S. Grand Rapids, MI 49503 (US) WEBB, Craig, P. Grand Rapids, MI 49341 (US) VANDE WOUDE, George, F. Ada, MI 49301 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)