VISUAL FUNCTION DISORDER IMPROVING AGENTS

(19)

(11)

EP 1 378 247 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 158(3) EPC

(48)	Corrigendum issued on:
	22.12.2004 Bulletin 2004/52

(43)	Date of publication:
	07.01.2004 Bulletin 2004/02

(21)	Application number: 02717107.3

(22)	Date of filing: 11.04.2002

(51)

International Patent Classification (IPC)⁷: A61K 45/00, A61K 31/16, A61K 31/337, A61K 31/415, A61K 31/437, A61K 31/4375, A61K 31/44, A61K 31/4409, A61K 31/4439, A61K 31/444, A61K 31/4545, A61K 31/50, A61K 31/505, A61K 31/519, A61K 31/52, A61P 25/00, A61P 27/02, A61P 43/00
// (C07D213/75, 213:79, 213:82, 213:89, 231:40, 237:20, 239:42)

(86)	International application number:
	PCT/JP2002/003590

(87)	International publication number:
	WO 2002/083175 (24.10.2002 Gazette 2002/43)

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
	Designated Extension States:
	AL LT LV MK RO SI

(30)

Priority:

11.04.2001 JP 2001113329
03.10.2001 JP 2001308010

(71)	Applicants:
	Senju Pharmaceutical Co., Ltd. Osaka-shi, Osaka 541-0046 (JP) Mitsubishi Pharma Corporation Osaka-shi, Osaka 541-0046 (JP)

(72)	Inventors:
	TAKAYAMA, Yoshiko Kobe-shi, Hyogo 655-0003 (JP) YOSHIDA, Yukuo Kobe-shi, Hyogo 651-1203 (JP) UEHATA, Masayoshi, c/o MITSUBISHI PHARMA CORP. Tokyo 103-8405 (JP)

(74)	Representative: von Kreisler, Alek, Dipl.-Chem. et al
	Deichmannhaus am Dom, Postfach 10 22 41 50462 Köln 50462 Köln (DE)

(54)	VISUAL FUNCTION DISORDER IMPROVING AGENTS

(57) The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly (R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide, as an effective component. This agent has axon of the retinal ganglion cellal extension promoting action and optic nerve cell regeneration promoting action, and is useful for the treatment of a visual function disorder associated with various eye diseases caused by damage, defects, degeneration and the like in the retinal or optic nerve.