(19)
(11) EP 1 379 493 A2

(12)

(88) Date of publication A3:
18.09.2003

(43) Date of publication:
14.01.2004 Bulletin 2004/03

(21) Application number: 02723329.5

(22) Date of filing: 21.03.2002
(51) International Patent Classification (IPC)7C07C 217/58, A61K 31/395, A61K 31/131, A61P 3/00, A61P 25/00, C07D 295/08, C07D 295/12, C07C 217/20, C07C 311/05, C07C 311/13, C07C 311/18, C07C 237/08, C07D 295/14, C07C 217/74, C07C 271/34, C07C 323/62, C07C 271/24, C07C 233/73, C07C 237/32, C07C 311/17, C07C 409/12
(86) International application number:
PCT/US2002/006644
(87) International publication number:
WO 2002/076925 (03.10.2002 Gazette 2002/40)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 23.03.2001 US 278230 P

(71) Applicant: Eli Lilly and Company
Indianapolis, IN 46206-6288 (US)

(72) Inventors:
  • BEAVERS, Lisa, Selsam
    Franklin, IN 46131 (US)
  • GADSKI, Robert, Alan
    Indianapolis, IN 46208 (US)
  • HIPSKIND, Philip, Arthur
    New Palestine, IN 46143 (US)
  • LINDSLEY, Craig, William
    Schwenxsville, PA 19473 (US)
  • LOBB, Karen, Lynn
    Indianapolis, IN 46219 (US)
  • NIXON, James, Arthur
    Indianapolis, IN 46219 (US)
  • PICKARD, Richard, Todd
    Noblesville, IN 46060 (US)
  • SCHAUS, John, Mehnert
    Zionsville, IN 46077 (US)
  • TAKAKUWA, Takako
    Indianapolis, IN 46237 (US)
  • WATSON, Brian, Morgan
    Carmel, IN 46033 (US)

(74) Representative: Burnside, Ivan John 
Eli Lilly and Company LimitedEuropean Patent OperationsErl Wood ManorSunninghill Road
Windlesham, Surrey GU20 6PH
Windlesham, Surrey GU20 6PH (GB)

   


(54) NON-IMIDAZOLE ARYL ALKYLAMINES COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES