(19)

(11)

EP 1 381 360 A1

(12)

(43) Date of publication: 21.01.2004 Bulletin 2004/04 (21) Application number: 02723701.5 (22) Date of filing: 28.03.2002

(51) International Patent Classification (IPC)7: A61K 31/41 (86) International application number: PCT/US2002/009954 (87) International publication number: WO 2002/078697 (10.10.2002 Gazette 2002/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.03.2001 US 279563 P (71) Applicant: SmithKline Beecham Corporation Philadelphia, PA 19103 (US)	(72) Inventors: MARINO, Joseph, P., Jr. King of Prussia, PA 19406 (US) THOMPSON, Scott, K. King of Prussia, PA 19406 (US) VEBER, Daniel, F. Ambler, PA 19002 (US) (74) Representative: Giddings, Peter John, Dr. et al GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)