(19)

(11)

EP 1 381 622 A2

(12)

(88) Date of publication A3: 30.10.2003 (43) Date of publication: 21.01.2004 Bulletin 2004/04 (21) Application number: 02749512.6 (22) Date of filing: 19.03.2002

(51) International Patent Classification (IPC)7: C07K 1/00 (86) International application number: PCT/US2002/008279 (87) International publication number: WO 2002/090526 (14.11.2002 Gazette 2002/46)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.03.2001 US 277340 P 19.07.2001 US 306171 P 13.11.2001 US 331287 P (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) RUBEN, Steven, M. Olney, MD 20850 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)