(19)

(11)

EP 1 381 678 A2

(12)

(88) Date of publication A3: 30.10.2003 (43) Date of publication: 21.01.2004 Bulletin 2004/04 (21) Application number: 01994151.7 (22) Date of filing: 01.11.2001

(51) International Patent Classification (IPC)7: C12N 9/90 (86) International application number: PCT/US2001/046301 (87) International publication number: WO 2002/059283 (01.08.2002 Gazette 2002/31)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.11.2000 US 245458 P 12.12.2000 US 255107 P (71) Applicant: Incyte Genomics, Inc. Palo Alto, CA 94304 (US)

(72) Inventors: BAUGHN, Mariah, R. San Leandro, CA 94577 (US) YUE, Henry Sunnyvale, CA 94087 (US) LU, Yan Mountain View, CA 94040 (US) DING, Li Creve Coeur, Missouri 63141 (US) TANG, Y., Tom San Jose, CA 95118 (US) GANDHI, Ameena, R. San Francisco, CA 94118 (US) HAFALIA, April, J., A. Daly City, CA 94015 (US) LAL, Preeti, G. Santa Clara, CA 95056 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)