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(11)

EP 1 381 688 A1

(12)

(43) Date of publication: 21.01.2004 Bulletin 2004/04 (21) Application number: 02733591.8 (22) Date of filing: 24.04.2002

(51) International Patent Classification (IPC)7: C12P 1/02, C12N 1/14, A61K 38/48, A61K 35/72, A61K 35/78 (86) International application number: PCT/NL2002/000272 (87) International publication number: WO 2002/086136 (31.10.2002 Gazette 2002/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.04.2001 EP 01201510 (71) Applicant: N.V. Nutricia 2700 MA Zoetermeer (NL)

(72) Inventors: KIERS, Jeroen, Lucas NL-2582 CT Den Haag (NL) NOUT, Martinus, Johannes, Robertus NL-6705 AX Wageningen (NL) ROMBOUTS, Franciscus, Maria NL-6666 LD Heteren (NL) KOOPS, Bart, Christian NL-3524 CA Utrecht (NL) VAN LAERE, Katrien, Maria, Jozefa NL-6666 WS Heteren (NL) WISSING, Elmo NL-3732 VG De Bilt (NL) HAGEMAN, Robert, Johan, Joseph NL-6705 CT Wageningen (NL) VAN DER MEULEN, Jan NL-8253 CS Dronten (NL) (74) Representative: van Westenbrugge, Andries  Nederlandsch OctrooibureauP.O. Box 29720 2502 LS The Hague 2502 LS The Hague (NL)