(19)
(11) EP 1 383 491 A2

(12)

(88) Date of publication A3:
17.04.2003

(43) Date of publication:
28.01.2004 Bulletin 2004/05

(21) Application number: 02733871.4

(22) Date of filing: 22.03.2002
(51) International Patent Classification (IPC)7: A61K 31/335
(86) International application number:
PCT/US2002/008718
(87) International publication number:
WO 2002/078620 (10.10.2002 Gazette 2002/41)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.03.2001 US 277754 P

(71) Applicant: Bristol-Myers Squibb Company
Princeton, NJ 08543-4000 (US)

(72) Inventors:
  • VIVAT-HANNAH, Valérie, Sandrine
    Philadelphia, PA 19147 (US)
  • LORENZI, Matthew, V.
    Philadelphia, PA 19147 (US)
  • GOTTARDIS, Marco, M.
    Princeton, NJ 08540 (US)
  • ZUSI, Fred, Christopher
    Hamden, CT 06514 (US)

(74) Representative: VOSSIUS & PARTNER 
Siebertstrasse 4
81675 München
81675 München (DE)

   


(54) SYNERGISTIC COMBINATIONS OF RETINOID RECEPTOR LIGANDS AND SELECTED CYTOTOXIC AGENTS FOR TREATMENT OF CANCER