(19)

(11)

EP 1 383 495 A1

(12)

(43) Date of publication: 28.01.2004 Bulletin 2004/05 (21) Application number: 02707828.6 (22) Date of filing: 15.03.2002

(51) International Patent Classification (IPC)7: A61K 31/381, A61K 31/38, A61K 31/4535, A61P 15/12 (86) International application number: PCT/US2002/005113 (87) International publication number: WO 2002/078691 (10.10.2002 Gazette 2002/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 29.03.2001 US 279896 P 11.01.2002 US 348084 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: WALLACE, Owen, Brendan Zionsville, IN 46077 (US) GARNETT, Timothy, John Indianapolis, IN 46220 (US) (74) Representative: Hiscock, Ian James et al European Patent Operations,Eli Lilly and Company Limited,Lilly Research Centre,Erl Wood Manor,Sunninghill Road Windlesham GU20 6PH Windlesham GU20 6PH (GB)