(19)

(11)

EP 1 383 530 A2

(12)

(88) Date of publication A3: 13.11.2003 (43) Date of publication: 28.01.2004 Bulletin 2004/05 (21) Application number: 98953599.2 (22) Date of filing: 15.10.1998

(51) International Patent Classification (IPC)7: A61K 38/39 (86) International application number: PCT/US1998/021866 (87) International publication number: WO 2000/021978 (20.04.2000 Gazette 2000/16)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 13.10.1998 US 104044 P (71) Applicants: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US) TRUSTEES OF TUFTS COLLEGE Medford, MA 02155 (US)	(72) Inventors: BRUNKEN, William, Joseph Canton, MA 02021 (US) LIBBY, Richard, Thomas Hingham, MA 02043 (US) HUNTER, Dale, Donald Canton, MA 02021 (US) BURGESON, Robert, Eugene Marblehead, MA 01945 (US) (74) Representative: Ruffles, Graham Keith et al Marks & Clerk,66-68 Hills Road Cambridge,Cambridgeshire CB2 1LA Cambridge,Cambridgeshire CB2 1LA (GB)