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EP 1 383 541 A1

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(43) Date of publication: 28.01.2004 Bulletin 2004/05 (21) Application number: 02753692.9 (22) Date of filing: 22.03.2002

(51) International Patent Classification (IPC)7: A61K 48/00, A61K 49/00, A61B 8/00, A61B 10/00, C07H 21/00, C07H 21/02, C07H 21/04, C12N 5/10, C12N 5/14, C12N 5/16, C12N 5/22, C12N 13/00, C12N 15/00, C12N 15/63, C12N 15/65, C12N 15/88, C12N 15/74, C12N 15/82, C12N 15/85, C12P 21/00, C12P 21/02 (86) International application number: PCT/US2002/009262 (87) International publication number: WO 2002/076508 (03.10.2002 Gazette 2002/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.03.2001 US 815979 22.03.2001 US 815981 28.02.2002 US 86745 (71) Applicant: Chromos Molecular Systems, Inc. Burnaby, BC V5A 1W9 (CA)

(72) Inventors: DEJONG, Gary North Vancouver, BC V7R 2E9 (CA) VANDERBYL, Sandra, Louise Burnaby, BC V3J 1A4 (CA) OBERLE, Volker NL-9737 NS Groningen (NL) HOEKSTRA, Dirk NL-9801 GJ Zuidhorn (NL) DRAYER, Jan Geyserville, CA 95441 (US) TAK, Paul, Peter NL-2314 GD Leiden (NL) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)