(19)

(11)

EP 1 385 459 A2

(12)

(88) Date of publication A3: 20.02.2003 (43) Date of publication: 04.02.2004 Bulletin 2004/06 (21) Application number: 02757900.2 (22) Date of filing: 01.04.2002

(51) International Patent Classification (IPC)7: A61F 13/00 (86) International application number: PCT/US2002/010057 (87) International publication number: WO 2002/078602 (10.10.2002 Gazette 2002/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 30.03.2001 US 280533 P (71) Applicant: Elan Pharmaceuticals, Inc. San Diego, CA 92121-4204 (US)	(72) Inventors: MARTIN, Debra, A. Sunrise, FL 33323 (US) MIRANDA, Jesus Miami, FL 33156 (US) VANEGAS, Adolfo, Leonel Miami Lakes, FL 33015 (US) (74) Representative: Gillam, Francis Cyril et al SANDERSON & CO.European Patent Attorneys34, East Stockwell Street ColchesterEssex CO1 1ST ColchesterEssex CO1 1ST (GB)