(19)

(11)

EP 1 385 821 A2

(12)

(88) Date of publication A3: 27.11.2003 (43) Date of publication: 04.02.2004 Bulletin 2004/06 (21) Application number: 02725119.8 (22) Date of filing: 12.03.2002

(51) International Patent Classification (IPC)7: C07C 335/00, C07C 273/00, C07C 275/00, C07C 331/00, C07C 381/00, C07C 303/00, C07C 307/00, C07C 309/00, C07C 311/00, C07C 315/00, C07C 317/00, C07C 305/00, C07C 327/00, C07C 333/00, C07C 329/00, C07D 245/00, C07D 517/00, C07D 205/00, C07D 205/12, C07D 513/00, C07D 205/08 (86) International application number: PCT/US2002/007426 (87) International publication number: WO 2002/072020 (19.09.2002 Gazette 2002/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 12.03.2001 US 275223 P (71) Applicant: Cerno Biosciences, LLC. Boston, MA 02116 (US)	(72) Inventors: ALBERTE, Randall, S. Falmouth, ME 04105 (US) SMITH, Robert, D. Falmouth, ME 04105 (US) (74) Representative: Hedley, Nicholas James Matthew et al Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)