(19)

(11)

EP 1 385 831 A2

(12)

(88) Date of publication A3: 19.12.2002 (43) Date of publication: 04.02.2004 Bulletin 2004/06 (21) Application number: 02717913.4 (22) Date of filing: 11.04.2002

(51) International Patent Classification (IPC)7: C07D 239/54, A61P 25/08, A61K 31/505, C07D 239/96, C07D 473/06, C07D 491/04, C07D 405/04 (86) International application number: PCT/CA2002/000512 (87) International publication number: WO 2002/083651 (24.10.2002 Gazette 2002/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.04.2001 US 282987 P 23.04.2001 US 285940 P 07.08.2001 US 310748 P 13.03.2002 US 99934 (71) Applicant: QUEEN'S UNIVERSITY AT KINGSTON KingstonOntario K7L 3N6 (CA)	(72) Inventors: WEAVER, Donald, F. Halifax, Nova Scotia B3M 3R4 (CA) GUILLAIN, Buhendwa, Musole Kingston, Ontario K7K 4S3 (CA) CARRAN, John, R. Kingston, Ontario K7L 3S6 (CA) JONES, Kathryn Kingston, Ontario K7L 3E5 (CA) (74) Representative: Lock, Graham James et al Fry Heath & Spence LLPThe GablesMassetts Road Horley,Surrey RH6 7DQ Horley,Surrey RH6 7DQ (GB)