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EP 1 385 954 A2

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(88) Date of publication A3: 27.11.2003 (43) Date of publication: 04.02.2004 Bulletin 2004/06 (21) Application number: 01996229.9 (22) Date of filing: 11.12.2001

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12N 1/21, C12N 5/10, A01K 67/027, C12N 15/00, C07K 16/18, C12Q 1/68, A61K 38/17, G01N 33/68 (86) International application number: PCT/US2001/047871 (87) International publication number: WO 2002/048368 (20.06.2002 Gazette 2002/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 14.12.2000 US 255754 P 21.12.2000 US 257605 P 19.01.2001 US 262855 P (71) Applicant: Incyte Genomics, Inc. Palo Alto, CA 94304 (US)

(72) Inventors: YUE, Henry Sunnyvale, CA 94087 (US) DING, Li Creve Coeur, Missouri, 63141 (US) TRIBOULEY, Catherine, M. San Francisco, CA 94107 (US) TRAN, Bao Santa Clara, CA 95051 (US) DUGGAN, Brendan, M. Sunnyvale, CA 94086 (US) HONCHELL, Cynthia, D. San Carlos, CA 94070 (US) BAUGHN, Mariah, R. San Leandro, CA 94577 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)