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(11)

EP 1 386 002 A1

(12)

(43) Date of publication: 04.02.2004 Bulletin 2004/06 (21) Application number: 02762116.8 (22) Date of filing: 16.04.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/24, C07H 21/04 (86) International application number: PCT/US2002/011931 (87) International publication number: WO 2002/083955 (24.10.2002 Gazette 2002/43)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.04.2001 US 284409 P (71) Applicant: Applera Corporation Foster City, CA 94404 (US)	(72) Inventors: SPIER, Eugene Palo Alto, CA 94306 (US) BOYD, Victoria, L. San Carlos, CA 94070 (US) (74) Representative: Grund, Martin, Dr. et al Dr. Volker Vossius,Patentanwaltskanzlei,Geibelstrasse 6 81679 München 81679 München (DE)