(19)

(11)

EP 1 387 692 A2

(12)

(88) Date of publication A3: 14.08.2003 (43) Date of publication: 11.02.2004 Bulletin 2004/07 (21) Application number: 01987086.4 (22) Date of filing: 09.11.2001

(51) International Patent Classification (IPC)7: A61K 39/00, C07K 5/00, G01N 33/567 (86) International application number: PCT/US2001/044138 (87) International publication number: WO 2002/042422 (30.05.2002 Gazette 2002/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.11.2000 US 710059 24.11.2000 US 721915 24.11.2000 US 722069 28.11.2000 US 724553 (71) Applicant: Arbor Vita Corporation Sunnyvale, CA 94086 (US)	(72) Inventors: LU, Peter Mountain View, CA 94043 (US) RABINOWITZ, Joshua, D. Mountain View, CA 94043 (US) SCHWEIZER, Johannes Mountain View, CA 94043 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)