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EP 1 389 185 A2

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(88) Date of publication A3: 06.03.2003 (43) Date of publication: 18.02.2004 Bulletin 2004/08 (21) Application number: 02728093.2 (22) Date of filing: 20.05.2002

(51) International Patent Classification (IPC)7: C07C 317/32, C07D 209/88, C07D 215/36, C07D 209/08, C07D 333/34, C07D 271/06, C07C 323/62, C07C 317/44, C07D 213/30, C07D 263/22, C07D 257/04, C07D 213/82, C07D 213/61, C07D 213/70, C07D 213/38, C07D 277/46, C07D 257/06, C07D 277/34, C07D 211/46, A61K 31/10, A61P 13/00 (86) International application number: PCT/JP2002/004865 (87) International publication number: WO 2002/094770 (28.11.2002 Gazette 2002/48)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.05.2001 AU PR523201 28.12.2001 AU PR978001 28.02.2002 AU PR079902 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shiOsaka 541-8514 (JP)

(72) Inventors: SAKURAI, Minoru,Fujisawa Pharmaceutical Co., Ltd. Osaka-shi, Osaka 541-8514 (JP) WASHIZUKA, K.,Fujisawa Pharmaceutical Co., Ltd. Osaka-shi, Osaka 541-8514 (JP) HAMASHIMA, H.,Fujisawa Pharmaceutical Co., Ltd Osaka-shi, Osaka 541-8514 (JP) TOMISHIMA, Y.,Fujisawa Pharmaceutical Co., Ltd Osaka-shi, Osaka 541-8514 (JP) IMANISHI, M.,Fujisawa Pharmaceutical Co., Ltd. Osaka-shi, Osaka 541-8514 (JP) KAYAKIRI, H.,Fujisawa Pharmaceutical Co., Ltd. Osaka-shi, Osaka 541-8514 (JP) TANIGUCHI, K.,Fujisawa Pharmaceutical Co., Ltd. Osaka-shi, Osaka 541-8514 (JP) TAKAMURA, F.,Fujisawa Pharmaceutical Co., Ltd. Osaka-shi, Osaka54 1-8514 (JP) (74) Representative: Gille Hrabal Struck Neidlein Prop Roos  Patentanwälte,Brucknerstrasse 20 40593 Düsseldorf 40593 Düsseldorf (DE)