ANALOGS OF THALIDOMIDE AS ANGIOGENESIS INHIBITORS

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EP 1 389 203 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	10.03.2010 Bulletin 2010/10

(45)	Mention of the grant of the patent:
	02.12.2009 Bulletin 2009/49

(21)	Application number: 02780964.9

(22)	Date of filing: 26.02.2002

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International Patent Classification (IPC):

C07D 403/04^(2006.01)
A61K 31/454^(2006.01)
A61K 31/402^(2006.01)
A61P 43/00^(2006.01)

C07D 209/48^(2006.01)
A61K 31/4035^(2006.01)
A61K 31/513^(2006.01)

(86)	International application number:
	PCT/US2002/005868

(87)	International publication number:
	WO 2002/068414 (06.09.2002 Gazette 2002/36)

(54)	ANALOGS OF THALIDOMIDE AS ANGIOGENESIS INHIBITORS ANALOGA VON THALIDOMID ALS ANGIOGENESEINHIBITOREN ANALOGUES DE THALIDOMIDE UTILISES COMME INHIBITEURS DE L'ANGIOGENESE

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

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Priority:

27.02.2001 US 271941 P

(43)	Date of publication of application:
	18.02.2004 Bulletin 2004/08

(73)	Proprietor: The Government of the United States of America, represented by The Secretary Department of Health and Human services
	Rockville, MD 20852 (US)

(72)	Inventors:
	FIGG, William, D. Fairfax, VA 22030 (US) EGER, Kurt 72072 Tuebingen (DE) TEUBERT, Uwe 31789 Hameln (DE) WEISS, Michael 06571 Wiehe-Garnbach (DE) GUETSCHOW, Michael, Pharmazeutisches Institut 53115 Bonn (DE) HECKER, Thomas 99094 Erfurt (DE) HAUSCHILDT, Sunna 04229 Leipzig (DE)

(74)	Representative: Gowshall, Jonathan Vallance
	Forrester & Boehmert Pettenkoferstrasse 20-22 80336 München 80336 München (DE)

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References cited: :

EP-A- 0 856 513
WO-A-97/37988

WO-A-94/20085
WO-A-98/03502

GÜTSCHOW M ET AL: "Aza analogues of thalidomide: synthesis and evaluation as inhibitors of tumor necrosis factor-alpha production in vitro." BIOORGANIC & MEDICINAL CHEMISTRY. ENGLAND APR 2001, vol. 9, no. 4, April 2001 (2001-04), pages 1059-1065, XP002207264 ISSN: 0968-0896
TEUBERT U ET AL: "5'-SUBSTITUTED THALIDOMIDE ANALOGS AS MODULATORS OF TNF-ALPHA*" ARCHIV DER PHARMAZIE, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIM, DE, vol. 331, no. 1, 1998, pages 7-12, XP002072713 ISSN: 0365-6233

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).