(19)

(11)

EP 1 390 053 A2

(12)

(88) Date of publication A3: 21.08.2003 (43) Date of publication: 25.02.2004 Bulletin 2004/09 (21) Application number: 02764353.5 (22) Date of filing: 25.04.2002

(51) International Patent Classification (IPC)7: A61K 38/00, C07K 1/00, C07K 14/59 (86) International application number: PCT/US2002/013269 (87) International publication number: WO 2002/085311 (31.10.2002 Gazette 2002/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.04.2001 US 285939 P (71) Applicant: Acevedo, Hernan F. Pittsburgh, PA 15237 (US)	(72) Inventor: Acevedo, Hernan F. Pittsburgh, PA 15237 (US) (74) Representative: Murphy, Colm Damien et al Boult Wade Tennant,Verulam Gardens,70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)