PYRUVATE-KINASE AS A NOVEL TARGET MOLECULE

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EP 1 390 525 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	04.03.2009 Bulletin 2009/10

(45)	Mention of the grant of the patent:
	13.08.2008 Bulletin 2008/33

(21)	Application number: 02748716.4

(22)	Date of filing: 23.05.2002

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International Patent Classification (IPC):

C12Q 1/48^(2006.01)
G01N 33/68^(2006.01)

G01N 33/50^(2006.01)

(86)	International application number:
	PCT/EP2002/005684

(87)	International publication number:
	WO 2002/095063 (28.11.2002 Gazette 2002/48)

(54)	PYRUVATE-KINASE AS A NOVEL TARGET MOLECULE PYRUVAT-KINASE ALS EINEM NEUEN ZIELMOLEKÜL PYRUVATE-KINASE UTILISEE COMME NOUVELLE MOLECULE CIBLE

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

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Priority:

23.05.2001 EP 01112601

(43)	Date of publication of application:
	25.02.2004 Bulletin 2004/09

(60)	Divisional application:
	08014232.6 / 1990422

(73)	Proprietor: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
	80539 München (DE)

(72)	Inventors:
	ULLRICH, Axel 80799 München (DE) STETÁK, Attila 3992 XK, Houten (NL) KÉRI, György H-1021 Budapest (HU)

(74)	Representative: Weiss, Wolfgang et al
	Weickmann & Weickmann Patentanwälte Postfach 86 08 20 81635 München 81635 München (DE)

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References cited: :

WO-A-98/35032

MAZUREK S ET AL: "The role of phosphometabolites in cell proliferation, energy metabolism, and tumor therapy." JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, vol. 29, no. 4, August 1997 (1997-08), pages 315-330, XP002940705 ISSN: 0145-479X
AISAKI K ET AL: "Unique apoptotic changes in two Friend erythroleukemia cell lines with R-type pyruvate kinase gene mutation." BLOOD, vol. 90, no. 10 SUPPL. 1 PART 2, 15 November 1997 (1997-11-15), page 3B XP008001525 Thirty-ninth Annual Meeting of the American Society of Hematology;San Diego, California, USA; December 5-9, 1997 ISSN: 0006-4971
NWANKWO J O: "Repression of cellular anaplerosis as the hypothesized mechanism of gamma-linolenic acid-induced toxicity to tumor cells." MEDICAL HYPOTHESES, vol. 56, no. 5, May 2001 (2001-05), pages 582-588, XP008001527 ISSN: 0306-9877
AISAKI KEN-ICHI ET AL: "Apoptotic changes precede mitochondrial dysfunction in red cell-type pyruvate kinase mutant mouse erythroleukemia cell lines." JAPANESE JOURNAL OF CANCER RESEARCH, vol. 90, no. 2, February 1999 (1999-02), pages 171-179, XP008001530 ISSN: 0910-5050
AIZAWA SHIN ET AL: "Effects of cyclic polylactate (CPL) on the growth of cloned leukemic cells in vitro." HEMATOLOGICAL ONCOLOGY, vol. 18, no. 2, June 2000 (2000-06), pages 51-60, XP008001526 ISSN: 0278-0232
KANNO H ET AL: "Red-cell type pyruvate kinase as an anti-apoptotic molecule in erythroid progenitor cells." BLOOD, vol. 94, no. 10 SUPPL. 1 PART 1, 15 November 1999 (1999-11-15), page 194a XP002194132 Forty-first Annual Meeting of the American Society of Hematology;New Orleans, Louisiana, USA; December 3-7, 1999 ISSN: 0006-4971
AISAKI KEN-ICHI ET AL: "Inhibition of glycolysis as well as mutations of pyruvate kinase gene causes apoptosis of erythroid progenitor cells both in vivo and vitro." BLOOD, vol. 96, no. 11 Part 1, 16 November 2000 (2000-11-16), page 596a XP002194133 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000 ISSN: 0006-4971
LUPULESCU AUREL: "Cancer cell metabolism: Its relevance to cancer treatment." CANCER INVESTIGATION, vol. 17, no. 6, 1999, pages 423-433, XP002214992 ISSN: 0735-7907
DANG CHI V ET AL: "Oncogenes in tumor metabolism, tumorigenesis, and apoptosis." JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, vol. 29, no. 4, August 1997 (1997-08), pages 345-354, XP008001528 ISSN: 0145-479X
MAZUREK SYBILLE ET AL: "Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: Role of pyruvate kinase type M2 and the glycolytic-enzyme complex." BIOCHEMICAL JOURNAL, vol. 356, no. 1, 2001, pages 247-256, XP002194134 ISSN: 0264-6021
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 1999 (1999-11) MAZUREK SYBILLE ET AL: "Energy metabolism in the involuting mammary gland." Database accession no. PREV200000187615 XP002194136 & IN VIVO (ATTIKI), vol. 13, no. 6, November 1999 (1999-11), pages 467-478, ISSN: 0258-851X
WANG JUN ET AL: "Cytomegalovirus inhibits p53 nuclear localization signal function." JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 78, no. 11, 2001, pages 642-647, XP002194135 ISSN: 0946-2716
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1994 MILAS LUKA ET AL: "Relation of apoptosis to cancer therapy." Database accession no. PREV199598143135 XP002194137 & IN VIVO (ATTIKI), vol. 8, no. 5, 1994, pages 665-673, ISSN: 0258-851X
Pubmed abstract PMID: 8703074 Berg, DT et al, Science (1996) vol 273, no 5280, pp 1389-1391.
Pubmed abstract PMID: 11598302 Mahal, LK et al, Science (2001) vol 294, no 5541, pp 380-381.

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