(19)

(11)

EP 1 395 285 A2

(12)

(88) Date of publication A3: 23.10.2003 (43) Date of publication: 10.03.2004 Bulletin 2004/11 (21) Application number: 02744162.5 (22) Date of filing: 17.05.2002

(51) International Patent Classification (IPC)7: A61K 39/395, A61K 39/00, A61K 39/38 (86) International application number: PCT/US2002/015982 (87) International publication number: WO 2002/092015 (21.11.2002 Gazette 2002/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.05.2001 US 291311 P 01.02.2002 US 353058 P 04.03.2002 US 361293 P (71) Applicants: Genome Therapeutics Corporation Waltham, MA 02453 (US) Wyeth Madison, New Jersey 07940 (US)

(72) Inventors: ALLEN, Kristina Hopkinton, MA 01748-3108 (US) ANISOWICZ, Anthony West Newton, MA 02465 (US) BHAT, Bheem, M. West Chester, PA 19380 (US) DAMAGNEZ, Veronique Framingham, MA 01701 (US) ROBINSON, John, Allen Downingtown, PA 19335 (US) YAWORSKY, Paul, J. Rockland, MA 02370 (US) (74) Representative: Duckworth, Timothy John et al J.A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)