(19)

(11)

EP 1 397 118 A1

(12)

(43) Date of publication: 17.03.2004 Bulletin 2004/12 (21) Application number: 01948522.6 (22) Date of filing: 20.06.2001

(51) International Patent Classification (IPC)7: A61K 7/48, A61K 7/02, A61K 7/021, A61K 7/027 (86) International application number: PCT/US2001/019702 (87) International publication number: WO 2003/000223 (03.01.2003 Gazette 2003/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati,Ohio 45202 (US)	(72) Inventors: MASUDA, Hisatoshi Moriyama-shi,Shiga 524-0046 (JP) ISHIGAMI, Mayu Ashiya-shi,Hyogo 659-0072 (JP) DECKNER, George, Endel Cincinnati, OH 45249 (US) (74) Representative: Wilding, Richard Alan et al Procter & Gamble Technical Centers Ltd.Rusham ParkWhitehall Lane Egham,Surrey TW20 9NW Egham,Surrey TW20 9NW (GB)