(19)

(11)

EP 1 399 119 A2

(12)

(88) Date of publication A3: 31.12.2003 (43) Date of publication: 24.03.2004 Bulletin 2004/13 (21) Application number: 01991293.0 (22) Date of filing: 13.12.2001

(51) International Patent Classification (IPC)7: A61K 7/16, A61K 7/26, A61K 35/64 (86) International application number: PCT/US2001/049032 (87) International publication number: WO 2002/047615 (20.06.2002 Gazette 2002/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 13.12.2000 US 255304 P (71) Applicants: University of Rochester Rochester,New York 14627 (US) Universidade Estadual de Campinas CEP-13081-970 Campinas, SP (BR)	(72) Inventors: BOWEN, William, H. Victor, NY 14564 (US) KOO, Hyun Rochester, NY 14620 (US) PARK, Yong Kun 13023-040 Campinas, SP (BR) CURY, Jaime, Aparecido CEP-13416-740 Piracicaba, SP (BR) ROSALEN, Pedro, Luiz CEP-13405-011 Piracicaba, SP (BR) (74) Representative: Miles, John Stephen et al Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)