(19)

(11)

EP 1 399 182 A2

(12)

(88) Date of publication A3: 31.12.2003 (43) Date of publication: 24.03.2004 Bulletin 2004/13 (21) Application number: 02702541.0 (22) Date of filing: 07.03.2002

(51) International Patent Classification (IPC)7: A61K 39/12, C07K 14/025, C07K 14/19, C12N 15/86 (86) International application number: PCT/GB2002/000975 (87) International publication number: WO 2002/070004 (12.09.2002 Gazette 2002/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.03.2001 GB 0105606 (71) Applicants: Xenova Research Limited Cambridge,Cambridgeshire CB4 0WG (GB) Leiden University Medical Center 2333 ZA Leiden (NL)	(72) Inventors: HICKLING, Julian, Kingdon Cambridge, Cambridgeshire CB1 7AB (GB) O'NEILL, Terry Balsham, Cambridgeshire CB1 6HL (GB) OFFRINGA, Rienk,Leiden Univ. Med. Center NL-2333 ZA Leiden (NL) VAN DER BURG, Sjoerd,Leiden Univ. Med. Center NL-2333 ZA Leiden (NL) (74) Representative: Sutcliffe, Nicholas Robert et al Mewburn Ellis,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)