(19)

(11)

EP 1 399 187 A2

(12)

(88) Date of publication A3: 20.06.2002 (43) Date of publication: 24.03.2004 Bulletin 2004/13 (21) Application number: 01983999.2 (22) Date of filing: 18.10.2001

(51) International Patent Classification (IPC)7: A61K 39/40, A61K 39/42, A61K 39/395, C12P 21/08, C07K 16/00 (86) International application number: PCT/US2001/032565 (87) International publication number: WO 2002/032375 (25.04.2002 Gazette 2002/17)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 18.10.2000 US 241344 P 17.10.2001 US 330396 P (71) Applicant: Sloan-Kettering InstituteFor Cancer Research New York,New York 10021 (US)	(72) Inventor: CHEUNG, Nai-Kong, V. Purchase, NY 10577 (US) (74) Representative: Lecca, Patricia  5b, rue des Motties 92260 Fontenay aux roses 92260 Fontenay aux roses (FR)