METHOD FOR PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND 10,11-DIHYDRO-10-0X0-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE

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EP 1 399 424 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	01.10.2008 Bulletin 2008/40

(45)	Mention of the grant of the patent:
	09.07.2008 Bulletin 2008/28

(21)	Application number: 02774050.5

(22)	Date of filing: 22.05.2002

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International Patent Classification (IPC):

C07D 223/22^(2006.01)
A61P 25/08^(2006.01)

A61K 31/55^(2006.01)

(86)	International application number:
	PCT/GB2002/002356

(87)	International publication number:
	WO 2002/096881 (05.12.2002 Gazette 2002/49)

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METHOD FOR PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND 10,11-DIHYDRO-10-0X0-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE

VERFAHREN ZUR HERSTELLUNG VON 10,11 DIHYDRO 10 HYDROXY 5H-DIBENZ/B,F/AZEPIN-5-CARBONSÄUREAMID UND 10,11 DIHYDRO 10 OXO-5H-DIBENZ/B,F/AZEPIN-5 CARBONSÄUREAMID

PROCEDE DE PREPARATION DU 10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE ET DU 10,11-DIHYDRO-10-0X0-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE

(84)	Designated Contracting States:
	AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
	Designated Extension States:
	SI

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Priority:

25.05.2001 GB 0112812

(43)	Date of publication of application:
	24.03.2004 Bulletin 2004/13

(60)	Divisional application:
	08075527.5 / 1958938

(73)	Proprietor: BIAL - Portela & Ca., S.A.
	Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado - Trofa (PT)

(72)	Inventor:
	LEARMONTH, David, Alexander P-4470-225 Maia (PT)

(74)	Representative: Curtis, Philip Anthony et al
	A.A. Thornton & Co. 235 High Holborn London WC1V 7LE London WC1V 7LE (GB)

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References cited: :

CH-A- 642 950
NL-A- 7 902 811

DE-A- 2 246 842
US-A- 5 753 646

K.M. BAKER, J. CSETENYI, A. FRIGERIO, P.L. MORSELLI: "a metabolite of carbamazepine" J. OF MED. CHEMISTRY, vol. 16, no. 6, 1973, pages 703-705, XP002209649 cited in the application
CANALI L ET AL: "Synthesis of resins with pendently-bound chiral manganese-salen complexes and use as heterogeneous asymmetric alkene epoxidation catalysts" REACTIVE & FUNCTIONAL POLYMERS, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 40, no. 2, 15 May 1999 (1999-05-15), pages 155-168, XP004164106 ISSN: 1381-5148
SENANAYAKE C H ET AL: "The Role of 4-(3-Phenylpropyl)pyridine N-Oxide (P3NO) in the Manganese-Salen-Catalyzed Asymmetric Epoxidation of Indene" TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 37, no. 19, 6 May 1996 (1996-05-06), pages 3271-3274, XP004029376 ISSN: 0040-4039
G. BELLUCCI, G. BERTI, C. CHIAPPE, A.LIPPI, F. MARIONI: "the metabolism of carbamazepine in Humans" J. MED.CHEM, vol. 30, 1987, pages 768-773, XP002209650 cited in the application
M. OSHIMA, H. YAMAZAKI, I. SHIMIZU, M. NISAR, J. TSUJI: "Palladium-Catalyzed selective hydrogenolysis of alkenyloxiranes with formic acid." J.AM.CHEM.SOC, vol. 111, 1989, pages 6280-6287, XP002209651
E.J. COREY: " a new Cr(IV) reagent for the catalytic oxidation of secundary alcohols" TETRAHEDRON LETTERS, vol. 26, no. 48, 1985, pages 5855-5858, XP001095121
GRANT S M ET AL: "OXCARBAZEPINE. A REVIEW OF ITS PHARMACOLOGY AND THERAPEUTIC POTENTIAL IN EPILEPSY, TRIGEMINAL NEURALGIA AND AFFECTIVE DISORDERS" DRUGS, ADIS INTERNATIONAL LTD, AT, vol. 43, no. 6, 1992, pages 873-888, XP002039768 ISSN: 0012-6667 cited in the application
BENES J ET AL: "Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carb oxamide Derivatives" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, 1999, pages 2582-2587, XP002206156 ISSN: 0022-2623 cited in the application
S.-I. MURAHASHI, T. NAOTA, Y. ODA, N. HIRAI: "Ruthenium catalysed oxidation of Alcohols with peracids" SYNLETT, vol. 7, 1995, XP001093973

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