(19)

(11)

EP 1 399 474 A2

(12)

(88) Date of publication A3: 24.12.2003 (43) Date of publication: 24.03.2004 Bulletin 2004/13 (21) Application number: 01985964.4 (22) Date of filing: 04.12.2001

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 16/18, C12N 15/12, C12N 15/62, C12Q 1/68, G01N 33/53, A61K 38/17, A61K 39/395, A61K 31/713 (86) International application number: PCT/US2001/043174 (87) International publication number: WO 2002/048361 (20.06.2002 Gazette 2002/25)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.12.2000 US 255850 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: BASINSKI, Margret, Barbara Indianapolis, IN 46208 (US) MICANOVIC, Radmila Indianapolis, IN 46236 (US) MILLS, Bradley, Jay Morristown, IN 46161 (US) SANKHAVARAM, Patanjali, Raghavacharya Carmel, IN 46033 (US) SU, Eric, Wen Carmel, IN 46032 (US) TSCHANG, Sheng-Hung, Rainbow Carmel, IN 46033 (US) VARGA, Gabor Indianapolis, IN 46278 (US) WANG, He Carmel, IN 46033 (US) (74) Representative: Kent, Lindsey Ruth  Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)