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(11)

EP 1 401 818 A2

(12)

(88) Date of publication A3: 06.03.2003 (43) Date of publication: 31.03.2004 Bulletin 2004/14 (21) Application number: 02741784.9 (22) Date of filing: 30.05.2002

(51) International Patent Classification (IPC)7: C07D 237/02, A61K 31/33, A61K 51/00, A61K 49/00, A61K 49/04, A61K 9/127, A61B 8/00 (86) International application number: PCT/US2002/017191 (87) International publication number: WO 2002/096367 (05.12.2002 Gazette 2002/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.05.2001 US 294309 P 31.07.2001 US 309104 P 15.08.2001 US 312435 P 11.10.2001 US 976254 (71) Applicant: Targesome, Inc. Palo Alto, CA 94303 (US)

(72) Inventors: DANTHI, Narasimhan, S. Mountain View, CA 94043 (US) CHOI, Steven, H. San Jose, CA 95123 (US) BEDNARSKI, Mark, David Los Altos, CA 94022 (US) WARTCHOW, Charles, Aaron San Carlos, CA 94070 (US) DECHENE, Neal, Edward Morgan Hill, CA 95037 (US) PEASE, John, S. Los Altos, CA 94025 (US) SHEN, Zhi, Min Palo Alto, CA 94306 (US) ZHANG, Michael San Jose, CA 95132 (US) TRULSON, Julie San Jose, CA 95126 (US) (74) Representative: Dörries, Hans Ulrich, Dr. et al Dörries, Frank-Molnia & Pohlman,Triftstrasse 13 80538 München 80538 München (DE)