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EP 1 401 830 A2

(12)

(88) Date of publication A3: 10.04.2003 (43) Date of publication: 31.03.2004 Bulletin 2004/14 (21) Application number: 02730582.0 (22) Date of filing: 13.05.2002

(51) International Patent Classification (IPC)7: C07D 403/04, C07D 239/96, C07D 471/04, C07D 487/04, C07D 498/08, C07D 487/06, C07D 471/06, C07D 409/04, C07D 495/04, C07D 413/04, C07D 491/04, A61P 31/04 (86) International application number: PCT/IB2002/001768 (87) International publication number: WO 2002/102793 (27.12.2002 Gazette 2002/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 19.06.2001 US 299249 P (71) Applicant: Warner-Lambert Company LLC Morris Plains,New Jersey 07950 (US)

(72) Inventors: ELLSWORTH, Edmund, LeePfizer Global R&D Ann Arbor, MI 48105 (US) SHOWALTER, Howard, Daniel, H.Pfizer Global R&D Ann Arbor,MI 48105 (US) POWELL, Sharon,AnnePfizer Global R&D Ann Arbor, MI 48105 (US) SANCHEZ, Joseph, PeterPfizer Global R&D Ann Arbor, MI 48105 (US) KERSCHEN, James, Alan Wilmington, DE 19808 (US) STIER, Michael, AndrewPfizer Global R&D Ann Arbor, MI 48105 (US) TRAN, Tuan,PhongPfizer Global R&D Ann Arbor, MI 48105 (US) (74) Representative: Tesch, Rudolf, Dr. et al Warner-Lambert Company LLCPatent Departmentc/o Gödecke GmbH 79090 Freiburg 79090 Freiburg (DE)